Vera Bradley's Weekender is super lightweight and holds a ton - great for day trips or a night at Grandmas.
Mia Bossi's are fashionable with awesome organization and are on the larger side.
The Oi Oi Hobos carry more like a Spicy.
I LOVE my LB Pixie as a backpack, but it is going to fulfill the bigger requirement of this.
Have you looked at Baby Kaed's? They are bigger so they may have a tote style that would work.
HTH!